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DOCTORADO EN CIENCIAS

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2005: Primera Graduación del Programa de Doctorado en Ciencias


En el orden usual, Dr. Gabriel Macaya (representante del Decano del SEP), Dr. Bruno Lomonte (director de tesis), Dr. Alberto Alape (asesor), Dra. Yamileth Angulo (primera graduada), Dr. José María Gutiérrez (asesor), y Dr. Esteban Chaves (representante del Director del Programa de Doctorado en Ciencias).

GRADUADOS

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Yamileth Angulo Ugalde, PhD

Tesis:

Fosfolipasas A2 miotóxicas de venenos de serpientes de la familia Viperidae: caracterización estructural y funcional.

Publicaciones de la Tesis

(I) Angulo Y, Olamendi-Portugal T, Possani L, Lomonte B (2000) Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue. International Journal of Biochemistry & Cell Biology 32, 63-71.

(II) Angulo Y, Olamendi-Portugal T, Alape-Girón A, Possani L, Lomonte B (2002) Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue. International Journal of Biochemistry & Cell Biology 34, 1268-1278.

(III) Watanabe L, Gava LM, Angulo Y, Lomonte B, Arni RK (2004) Crystallization of the Lys49 PLA2 homologue, myotoxin II, from the venom of Atropoides nummifer. Biochimica et Biophysica Acta 1703, 87-89.

(IV) Lomonte B, Angulo Y, Santamaría C (2003) Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms. Toxicon 42, 307-312.

(V) Angulo Y, Gutiérrez JM, Soares AM, Cho W, Lomonte B (2005) The myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation. Toxicon 46, 291-296.

(VI) Angulo Y, Lomonte B (2004) Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms. Cell Biochemistry and Function 23, 307-313.

(VII) Angulo Y, Lomonte B (2003) Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2. Biochemical Pharmacology 66, 1993-2000.

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Vitelbina Núñez Rangel, PhD

Tesis:

Aislamiento de una miotoxina tipo fosfolipasa A2 del veneno de Bothrops atrox de Colombia: caracterización, clonaje y neutralización por compuestos de origen vegetal

Publicaciones de la Tesis

(I) Nuñez V, Otero R, Barona J, Fonnegra R, Jiménez S, Osorio RG, Quintana JC, Díaz A (2004) Inhibition of the toxic effects of Lachesis muta, Crotalus durissus cumanensis and Micrurus mipartitus snake venoms by plant extracts. Pharmaceutical Biology 42, 49-54.

(II) Nuñez V, Arce V, Gutiérrez JM, Lomonte B (2004) Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox. Toxicon 44, 91-101.

(III) Nuñez V, Castro V, Murillo R, Ponce-Soto LA, Merfort I, Lomonte B (2005) Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolydilcatechol as active principle. Phytochemistry 66, 1017-1025.

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Rafael Monge Rojas, PhD

Tesis:

Ingesta de nutrientes en adolescentes y factores psicosociales asociados

Publicaciones de la Tesis

(I) Monge-Rojas R, Campos H, Fernández X (2005) Saturated and cis–and trans-unsaturated fatty acids intake in rural and urban Costa Rican adolescents. Journal of the American College of Nutrition 4 286-293.

(II) Monge-Rojas R (2001) Marginal vitamin and mineral intake of Costa Rican adolescents. Archives of Medical Research 32, 70-78.

(III) Monge-Rojas R, Nuñez H, Garita C, Chen-Mok M (2002) Psychosocial aspects of Costa Rican adolescents’ eating and physical activity patterns. Journal of Adolescent Health 31, 212-219. (IV) Monge-Rojas R, Garita C, Sánchez M, Muñoz L (2005) Barriers to and motivators for healthful eating as perceived by rural and urban Costa Rican adolescents. Journal of Nutrition Education and Behavior 37, 33-40.

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Alexandra Rucavado Romero, PhD

Tesis:

Componentes del veneno de Bothrops asper que afectan la hemostasis y su papel en el desarrollo del síndrome hemorrágico

Publicaciones de la Tesis

(I) Rucavado A, Soto M, Kamiguti AS, Theakston RD, Fox JW, Escalante T, Gutiérrez JM (2001) Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage. Thrombosis and Haemostasis 85, 710-715.

(II) Rucavado A, Soto M, Escalante T, Loría GD, Arni R., Gutiérrez JM (2005) Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom: toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. Thrombosis and Haemostasis 94, 123-131.

(III) Rucavado A, Escalante T, Gutiérrez JM (2004) Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation. Toxicon 43, 417-424.

(IV) Rucavado A, Escalante T, Texeira CF, Fernandes CM, Díaz C, Gutiérrez JM (2002) Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper. Mediators of Inflammation 11, 121-128.

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Mario Santoro, PhD

Tesis:

Ecología de los tremátodos digéneos y su acción patóena en los tejidos de la tortuga verde (Chelonia mydas) de Tortuguero, Caribe Norte de Costa Rica

Publicaciones de la Tesis

(I) Santoro M, Greiner EC, Morales JA, Rodríguez-Ortiz B (2006) Digenetic trematode community of nesting green sea turtles (Chelonia mydas) from Tortuguero National Park, Costa Rica. Journal of Parasitology 92, 1202-1206.

(II) Santoro M, Morales JA, Rodríguez-Ortiz B (2006) Spirorchiidiosis (Digenea: Spirorchiidae) and lesions associated with parasites in Caribbean green sea turtles (Chelonia mydas). The Veterinary Record (en prensa).

(III) Santoro M, Morales JA, Stacy B, Greiner EC (2006) Rameshwarotrema uterocrescens trematode parasitism of the oesophageal glands and associated oesophagitis in green turtles. The Veterinary Record 160, 59-60.

(IV) Santoro M, Hernández G, Caballero M, Garc?a F (2006) Aerobic bacterial flora of nesting green turtles (Chelonia mydas) from Tortuguero, Costa Rica. Journal of Zoo and Wildlife Medicine 37, 549-552.

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Fernando Chaves Mora, PhD

Tesis:

Papel de mediadores inflamatorios en los procesos de lesión tisular local posterior a inyecciones de venenos de serpientes del género Bothrops.

Publicaciones de la Tesis

(I) Chaves F, Teixeira CFP, Gutiérrez JM (2005). Role of TNF-alpha, IL-1beta and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice. Toxicon 45, 171-178.

(II) Teixeira CFP, Chaves F, Zamúner SR, Fernandes CM, Zuliani JP, Cruz-Hofling MA, Fernandes I, Gutiérrez JM (2005) Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom. International Journal of Experimental Pathology 86, 107-115.

(III) Chaves F, Teixeira CFP, Gutiérrez JM (2006). Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice. Inflammation Research 55, 1-9.

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Guillermo León Montero, PhD

Tesis:

Estudio de los mecanismos patogénicos que operan en las reacciones anafilactoides presentadas durante la administración de antivenenos.

Publicaciones de la Tesis

(I) León G, Lomonte B, Gutiérrez JM (2005) Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols. Toxicon 45, 123-128.

(II) Otero R, León G, Gutiérrez JM, Rojas G, Toro MF, Barona J, Rodríguez V, Díaz A, Núñez V, Quintana JC, Ayala S, Mosequera D, Conrado LL, Fernández D, Arroyo Y, Paniagua CA, López M, Ospina CE, Alzate C, Fernández J, Meza JJ, Silva JF, Ramírez P, Fabra PE, Ramírez E, Córdoba E, Arrieta AB, Warrell DA, Theakston RDG (2006) Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia. Transactions of the Royal Society of Tropical Medicine and Hygiene 100, 1173-1182.

(III) León G, Rodríguez M, Rucavado A, Fernandez I, Lomonte B, Gutiérrez JM (2007) Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations. Biologicals 35, 5-11.

(IV) Herrera M, León G, Segura A, Meneses F, Lomonte B, Chippaux JP, Gutiérrez JM (2005) Factors associated with adverse reactions induced by whole IgG preparations: comparison between horse, sheep and camel IgGs. Toxicon 46, 775-781.

(V) León G, Segura A, Herrera M, Otero R, França FO, Barbaro KC, Cardoso JLC, Hui F, Medeiros CR, Lopes JC, Sant’Ana Malaque CM, Lomonte B, Gutiérrez JM (2008) Human heterophilic antibodies against equine immunoglobulins: Assessment of their role in the early adverse reactions to antivenom administration. Transactions of the Royal Society of Tropical Medicine and Hygiene (en prensa).

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Omar Ariel Dupuy Loo, PhD

Tesis:

Efecto inmunosupresor y antitumoral del millerenólido y la thieleanina sobre macrófagos, linfocitos y melanoma B16/BL6.

Publicaciones de la Tesis

(I) Dupuy O, Murillo R, Bonilla J (2008) Actividad supresora del millerenólido sobre células mononucleares de sangre periférica humana. Revista Médica de Chile 136, 64-72.

(II) Dupuy O, Murillo R, Bonilla J (2008) Lactonas sesquiterpénicas de Viguiera sylvatica y Decachaeta thieleana (Asteraceae) modulan la producción de óxido nítrico y la fagocitosis de macrófagos RAW. Revista de Biología Tropical 56 (en prensa).

(III) Taylor P, Dupuy O, Bonilla J, Murillo R (2008) Anticancer activities of two sesquiterpene lactones, millerenolide and thieleanin isolated from Viguiera sylvatica and Decachaeta thieleana. Fitoterapia 79, 428-432.

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Lela Taliashvili, PhD

Tesis:

Física Geoefectividad de prominencias solares.

Publicaciones de la Tesis

(I) Belov AV, Ishkov VN, Taliashvili LI, Shatashvili LKh (1991) Variaciones de rayos cósmicos relacionados con la desaparición de filamentos solares. Geomagnetizm i Aeronomia 31, 345-347.

(II) Taliashvili L, Mouradian Z, Páez J (2008) Dynamic disappearance of prominences and their geoeffectiveness. Geofísica Internacional 47, 279-285.

(III) Taliashvili L, Mouradian Z, Páez J (2008) Dynamic and thermal disappearance of prominences and their geoeffectiveness. Solar Physics (en prensa).

CONTÁCTENOS


DOCTORADO EN CIENCIAS


Dra. Ana Mercedes Pérez Carvajal, Directora del Programa

Ubicación:  Centro Nacional de Ciencia y Tecnología de Alimentos CITA, Facultad de Ciencias Agroalimentarias,
Ciudad Universitaria Rodrigo Facio, San Pedro, Montes de Oca, San José, Costa Rica.
Horario de atención: L-V de 8 a 12 m.d. y de 1 a 3:45 p.m. (virtual)
Teléfono: (506)2511-7212 / 2511-8833 / 2511-7223

Escríbanos: click aquí

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