Herramientas de Accesibilidad

 

 

Dra. Cecilia Díaz Oreiro
Periodo:  2012-2016  

Área de Salud

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Dirigió el Programa de Ciencias Biomédicas con sede en la Escuela de Medicina de la UCR desde el 2006 al 2012, a partir de este último año y hasta mediados del 2016 se desempeñó como decana de Sistema de Estudios de Posgrado (SEP) de la Universidad de Costa Rica (UCR).

Tuvo participación como docente a nivel de grado en el Departamento de Bioquímica de la Escuela de Medicina y a nivel de posgrado en el SEP.

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Formación Académica


Ph.D. Ciencias Biomédicas, University of Texas at Houston – Health Science Center en el Houston-MD Anderson Cáncer Center, Estados Unidos de América,1998.

M.Sc. Posgrado de Ciencias Biomédicas, Universidad de Costa Rica con énfasis en Fisiología, 1992.

Bach. Biología, Universidad de Costa Rica, 1987.

 

Experiencia Laboral


Catedrática, Instituto Clodomiro Picado, Facultad de Microbiología y Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica (UCR).

 

 

Actividades Investigación


Estudios de caracterización de venenos de varios organismos, que incluyen peces, escorpiones y serpientes.

Investigación en temas de cáncer gástrico, principalmente en la caracterización de mecanismos de metástasis y en la búsqueda de sustancias para la sensibilización de los tumores a la quimioterapia.

 

Actividades Acción Social


Actividades de acción social del Instituto Clodomiro Picado (ICP).

 

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Referencias bibliográficas

 

Alape-Girón, A., Moreira-Soto, A., Arguedas, M., Brenes, H., Buján, W., Corrales-Aguilar, E., Díaz, C., Echeverri, A., Flores-Díaz, M., Gómez, A., Hernández, A., Herrera, M., León, G., Macaya, R., Molina-Mora, J. A., Mora, J., Narayanan, A., Sanabria, A., Sánchez, A., … Gutiérrez, J. M. (2021). Heterologous hyperimmune polyclonal antibodies against Sars-Cov-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.743325 

Alfaro-Chinchilla, A., Segura, Á., Gómez, A., Díaz, C., Corrales, G., Chacón, D., Arguedas, M., Estrada, R., Gutiérrez, J. M., & León, G. (2021). Expanding the neutralization scope of the Central American antivenom (Polival-icp) to include the venom of Crotalus durissus pifanorum. Journal of Proteomics, 246, Artículo 104315. https://doi.org/10.1016/j.jprot.2021.104315 

Andrião-Escarso, S. H., Soares, A. M., Rodrgues, V. M., Angulo, Y., Díaz, C., Lomonte, B., Gutiérrez, J. M., & Giglio, J. R. (2000). Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu. Biochimie, 82(8), 755-763. https://doi.org/10.1016/S0300-9084(00)01150-0 

Arce, F., Gätjens-Boniche, O., Vargas, E., Valverde, B., & Díaz, C. (2005). Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2. Cancer Letters, 229(2), 271-281. https://doi.org/10.1016/j.canlet.2005.06.047 

Arguedas, M., Umaña, D., Moscoso, E., García, A., Pereira, C., Sánchez, A., Durán, G., Cordero, D., Sánchez, A., Segura, Á., Vargas, M., Herrera, M., Villalta, M., Gómez, A., Salas, C., Díaz, C., María Gutiérrez, J., & León, G. (2022). Comparison of adjuvant emulsions for their safety and ability to enhance the antibody response in horses immunized with African snake venoms. Vaccine: X, 12, Artículo 100233. https://doi.org/10.1016/j.jvacx.2022.100233 

Arni, R. K., Fontes, M. R. M., Barberato, C., Gutiérrez, J. M., Dı́az, C., & Ward, R. J. (1999). Crystal structure of myotoxin ii, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani. Archives of Biochemistry and Biophysics, 366(2), 177-182. https://doi.org/10.1006/abbi.1999.1210 

Arroyo, V., Moya Vargas, E., Díaz-Oreiro, C., Arce Flores, D., & Cárdenas Valenzuela, P. (2016). Instructivo para la autoevaluación de los posgrados. Universidad de Costa Rica.

Borges, A., Arias, A. R. de, Lima, S. de A., Lomonte, B., Díaz, C., Chávez-Olórtegui, C., Graham, M. R., Kalapothakis, E., Coronel, C., & Roodt, A. R. de. (2020). Genetic and toxinological divergence among populations of Tityus trivittatus Kraepelin, 1898 (Scorpiones: Buthidae) inhabiting Paraguay and Argentina. PLOS Neglected Tropical Diseases, 14(12), Artículo e0008899. https://doi.org/10.1371/journal.pntd.0008899 

Bregge-Silva, C., Nonato, M. C., de Albuquerque, S., Lee Ho, P., Junqueira de Azevedo, I. L. M., Vasconcelos Diniz, M. R., Lomonte, B., Rucavado, A., Díaz, C., Gutiérrez, J. M., & Arantes, E. C. (2012). Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom. Toxicon, 60(7), 1263-1276. https://doi.org/10.1016/j.toxicon.2012.08.008

Brenes, O., Arce, F., Gätjens-Boniche, O., & Díaz, C. (2007). Characterization of cell death events induced by anti-neoplastic drugs cisplatin, paclitaxel and 5-fluorouracil on human hepatoma cell lines: Possible mechanisms of cell resistance. Biomedicine & Pharmacotherapy, 61(6), 347-355. https://doi.org/10.1016/j.biopha.2007.02.007 

Brenes, O., Muñóz, E., Roldán-Rodríguez, R., & Díaz, C. (2010). Cell death induced by Bothrops asper snake venom metalloproteinase on endothelial and other cell lines. Experimental and Molecular Pathology, 88(3), 424-432. https://doi.org/10.1016/j.yexmp.2010.02.002 

Chacón, J., Chaves-Araya, S., Mena, G., Chang-Castillo, A., Díaz, C., Bonilla, F., Sasa, M., Calvete, J. J., Sanz, L., Gutiérrez, J. M., Lomonte, B., & Fernández, J. (2025). Snake venomics of the arboreal talamancan palm-pitviper, bothriechis nubestris , provides clues on the origin of a phenotypic dichotomy between type-i and type-ii venoms. Journal of Proteome Research, acs.jproteome.4c01041. https://doi.org/10.1021/acs.jproteome.4c01041 

Chaverri, C., Díaz, C., & Cicció, J. F. (2011). Chemical analysis of essential oils from ocotea Gomezii W. C. Burger and Ocotea morae Gómez-Laur.(Lauraceae) Collected at «reserva biológica Alberto M. Brenes» in Costa Rica and their cytotoxic activity on tumor cell lines. Journal of the Brazilian Chemical Society, 22(4), 741-745. https://doi.org/10.1590/S0103-50532011000400018 

Chaverri, C., Díaz, C., & Cicció, J. F. (2011). Leaf essential oil of manekia naranjoana (Piperaceae) from Costa Rica and its cytotoxic activity. Natural Product Communications, 6(1), 145-148. https://doi.org/10.1177/1934578X1100600135 

Chaverri, C., Cicció, J. F., & Díaz, C. (2010). Chemical composition of aiouea costaricensis (Lauraceae) essential oils from Costa Rica and their cytotoxic activity on cell lines. Journal of Essential Oil Research, 22(6), 524-529. https://doi.org/10.1080/10412905.2010.9700389 

Cicció, J. F., Chaverri, C., & Díaz, C. (2009). Volatile compounds of Nectandra salicina (Lauraceae) from Costa Rica and their cytotoxic activity on cell lines. Química Nova, 32(2), 417-420. https://doi.org/10.1590/S0100-40422009000200028 

De Sousa, M. V., Morhy, L., Arni, R. K., Ward, R. J., Dı́az, C., & Gutiérrez, J. M. (1998). Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1384(2), 204-208. https://doi.org/10.1016/S0167-4838(98)00023-5 

Díaz, C., Alape, A., Lomonte, B., Olamendi, T., & Gutierrez, J. M. (1994). Cleavage of the Nh2-terminal octapeptide of bothrops asper myotoxic Lysine-49 phospholipase A2 reduces its membrane-destabilizing effect. Archives of Biochemistry and Biophysics, 312(2), 336-339. https://doi.org/10.1006/abbi.1994.1317 

Díaz, C., Balasubramanian, K., & Schroit, A. J. (1998). Synthesis of disulfide-containing phospholipid analogs for the preparation of head group-specific lipid antigens: Generation of phosphatidylserine antibodies. Bioconjugate Chemistry, 9(2), 250-254. https://doi.org/10.1021/bc970156x 

 Díaz, C., Chang-Castillo, A., Lomonte, B., Bonilla, F., Víquez, C., Alfaro-Chinchilla, A., Triana, F., & Sasa, M. (2022). Venomics of the scorpion Tityus ocelote (Scorpiones, buthidae): Understanding venom evolution in the subgenus archaeotityus. International Journal of Peptide Research and Therapeutics, 29(1), Artículo 2. https://doi.org/10.1007/s10989-022-10476-0 

Díaz, C., Chang-Castillo, A., & Ortiz, N. (2025). Histopathological characterization of skin and muscle lesions induced by Lionfish (Pterois volitans) venom in a murine experimental model. Journal of Venomous Animals and Toxins including Tropical Diseases, 31, Artículo e20240050.  https://doi.org/10.1590/1678-9199-JVATITD-2024-0050 

Díaz, C., Gutiérrez, J. M, & Lomonte, B. (1992). Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman’s pit viper) snake venom. Archives of Biochemistry and Biophysics, 298(1), 135-142. https://doi.org/10.1016/0003-9861(92)90104-5

Díaz, C., Gutiérrez, J. M, Lomonte, B., & Gené, J. A. (1991). The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: Relationship to phospholipase A2, anticoagulant and myotoxic activities. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1070(2), 455-460. https://doi.org/10.1016/0005-2736(91)90086-N 

Díaz, C., Gutiérrez, J. M, Lomonte, B., & Núñez, J. (1993). P-bromophenacyl bromide modification of bothrops asper myotoxin ii, a Lysine-49 phospholipase A2, affects its pharmacological activities. Toxicon, 31(9), 1202-1206. https://doi.org/10.1016/0041-0101(93)90136-7

Díaz, C., Lee, A. T., McConkey, D. J., & Schroit, A. J. (1999). Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells. Cell Death & Differentiation, 6(3), 218-226. https://doi.org/10.1038/sj.cdd.4400484 

Díaz, C., León, G., Rucavado, A., Rojas, N., Schroit, A. J., & Gutiérrez, J. M. (2001). Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A2: Role of negatively charged phospholipids as potential membrane binding sites. Archives of Biochemistry and Biophysics, 391(1), 56-64. https://doi.org/10.1006/abbi.2001.2386 

Díaz, C., Lomonte, B., Chang-Castillo, A., Bonilla, F., Alfaro-Chinchilla, A., Triana, F., Angulo, D., Fernández, J., & Sasa, M. (2024). Venomics of scorpion ananteris platnicki (Lourenço, 1993), a new world buthid that inhabits Costa Rica and Panama. Toxins, 16(8), 327. https://doi.org/10.3390/toxins16080327 

Díaz, C., Lomonte, B., Zamudio, F., & Gutiérrez, J. M. (1995). Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom. Natural Toxins, 3(1), 26-31. https://doi.org/10.1002/nt.2620030107 

Díaz, C., Mack-Prado, M., Bonilla, E., Chang-Castillo, A., Bonilla, F., Ortiz, N., Angulo, D., & Sasa, M. (2025). Venom composition of Tityus cerroazul (Scorpiones: Buthidae) reveals similarities with venoms of other scorpion species from northern South America. Toxicon, 262, Artículo 108385. https://doi.org/10.1016/j.toxicon.2025.108385 

Diaz, C., Morkowski, J., & Schroit, A. (1996). Generation of phenotypically aged phosphatidylserine-expressing erythrocytes by dilauroylphosphatidylcholine-induced vesiculation. Blood, 87(7), 2956-2961. https://doi.org/10.1182/blood.V87.7.2956.bloodjournal8772956 

Díaz, C., Quesada, S., Brenes, O., Aguilar, G., & Cicció, J. F. (2008). Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines. Natural Product Research, 22(17), 1521-1534. https://doi.org/10.1080/14786410701848154 

Díaz, C., Rivera, J., Lomonte, B., Bonilla, F., Diego-García, E., Camacho, E., Tytgat, J., & Sasa, M. (2019). Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): Composition, biochemical activities and in vivo toxicity for potential prey. Toxicon, 171, 7-19. https://doi.org/10.1016/j.toxicon.2019.09.021 

Díaz, C., & Schroit, A. J. (1996). Role of translocases in the generation of phosphatidylserine asymmetry. Journal of Membrane Biology, 151(1), 1-9. https://doi.org/10.1007/s002329900051 

Díaz, C., Serna-Gonzalez, M., Chang-Castillo, A., Lomonte, B., Bonilla, F., Alfaro-Chinchilla, A., Triana, F., & Sasa, M. (2023). Proteomic profile of the venom of three dark-colored Tityus (Scorpiones: Buthidae) from the tropical rainforests of Costa Rica. Acta Tropica, 248, Artículo 107031. https://doi.org/10.1016/j.actatropica.2023.107031 

Díaz, C., Valverde, L., Brenes, O., Rucavado, A., & Gutiérrez, J. M. (2005). Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells. Journal of Cellular Biochemistry, 94(3), 520-528. https://doi.org/10.1002/jcb.20322 

Díaz, C., Vargas, E., & Gätjens-Boniche, O. (2006). Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines. International Journal of Pharmaceutics, 325(1-2), 108-115. https://doi.org/10.1016/j.ijpharm.2006.06.034 

Díaz-Oreiro, C. (2016, 13 de julio). Las cosas en perspectiva: El caso de los Posgrados en Odontología. Semanario Universidad. https://semanariouniversidad.com/opinion/las-cosas-perspectiva-caso-los-posgrados-odontologia/ 

Díaz-Oreiro, C. (2015, 11 de agosto). La Autonomía no nos ha sido dada, sino reconocida. Semanario Universidad. https://historico.semanariouniversidad.com/opinion/la-autonomia-no-nos-ha-sido-dada-sino-reconocida/

Díaz-Oreiro, C. (2015, 22 de julio). Modelo de Atención en Salud y el fallo de la Sala IV. Semanario Universidad. https://historico.semanariouniversidad.com/opinion/modelo-de-atencion-en-salud-y-el-fallo-de-la-sala-iv/ 

Díaz-Oreiro, C. (2014, 26 de marzo). El interinato de funcionarios administrativos en el SEP. Semanario Universidad. https://historico.semanariouniversidad.com/opinion/el-interinato-de-funcionarios-administrativos-en-el-sep/  

Díaz-Oreiro, C. (2013, 06 de noviembre). El SEP en el VII Congreso Universitario. Semanario Universidad. https://historico.semanariouniversidad.com/opinion/el-sep-en-el-vii-congreso-universitario/ 

Díaz-Oreiro, C. (2013, 10 de julio). El tema de las especialidades médicas. Semanario Universidad. https://historico.semanariouniversidad.com/opinion/el-tema-de-las-especialidades-mdicas/ 

Díaz-Oreiro, C. (1998). Redistribution of plasma membrane phosphatidylserine during erythroid development (Publicación No. 9828234) [Tesis de doctorado, The University of Texas]. ProQuest Dissertation and Thesis Global  https://proquest.proxyucr.elogim.com/dissertations-theses/redistribution-plasma-membrane-phosphatidylserine/docview/304490615/se-2?accountid=28692 

Díaz-Oreiro, C. (1992). Caracterización bioquímica y biológica de dos toxinas aisladas del veneno de Bothrops godmani (toboba de altura) [Tesis de maestría inédita]. Universidad de Costa Rica.  

Díaz-Oreiro, C., & Gutiérrez, J. M. (1997). Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: Effects on enzymatic and pharmacological properties. Toxicon, 35(2), 241-252. https://doi.org/10.1016/S0041-0101(96)00128-6 

Díaz Oreiro, C., & Vargas Arroyo, M. (2013). Preclinical validation study of the anticancer traditional use of Uncaria tomentosa (Cat's claw). Revista Médica de la Universidad de Costa Rica, 6(1), 24-31. https://doi.org/10.15517/rmu.v6i1.8034 

Durán, G., Solano, G., Gómez, A., Cordero, D., Sánchez, A., Villalta, M., Sánchez, M., Díaz, C., Gutiérrez, J. M., & León, G. (2021). Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms. Toxicon: X, 12, Artículo 100087. https://doi.org/10.1016/j.toxcx.2021.100087 

Gutiérrez, J. M, Romero, M., Díaz, C., Borkow, G., & Ovadia, M. (1995). Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (Terciopelo). Toxicon, 33(1), 19-29. https://doi.org/10.1016/0041-0101(94)00138-X 

Gutiérrez, J. M., Rucavado, A., Chaves, F., Díaz, C., & Escalante, T. (2009). Experimental pathology of local tissue damage induced by Bothrops asper snake venom. Toxicon, 54(7), 958-975. https://doi.org/10.1016/j.toxicon.2009.01.038 

Gutiérrez, J. M., Rucavado, A., Escalante, T., & Díaz, C. (2005). Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage. Toxicon, 45(8), 997-1011. https://doi.org/10.1016/j.toxicon.2005.02.029 

Fernández, A., Fosdick, L. J., Marín, M. C., Diaz, C., McDonnell, T. J., Ananthaswamy, H. N., & McConkey, D. J. (1995). Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2. Oncogene, 10(4), 769-774.

García González, M., Escalante, C., & Díaz Oreiro, C. (2007). Antipyretic effect of the aqueous extract obtained from leaves of Neurolaena lobata (Asteraceae) on a pyretic model induced by brewer’s yeast. Revista Médica de la Universidad de Costa Rica, 1(1), Artículo 3. https://doi.org/10.15517/rmu.v1i1.7870 

Gómez, A., Sánchez, A., Durán, G., Cordero, D., Segura, Á., Vargas, M., Solano, D., Herrera, M., Chaves-Araya, S., Villalta, M., Sánchez, M., Arguedas, M., Díaz, C., Gutiérrez, J. M., & León, G. (2022). Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. And Echis spp. African snakes. PLOS Neglected Tropical Diseases, 16(8), Artículo e0010643. https://doi.org/10.1371/journal.pntd.0010643 

Gutiérrez, J. M., Núñez, J., Díaz, C., Cintra, A. C. O., Homsi-Brandeburgo, M. I., & Giglio, J. R. (1991). Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu. Experimental and Molecular Pathology, 55(3), 217-229. https://doi.org/10.1016/0014-4800(91)90002-F 

Jatunuv, S., Quesada, S., Díaz, C., & Murillo, E. (2010). Carotenoid composition and antioxidant activity of the raw and boiled fruit mesocarp of six varieties of Bactris gasipaes. Archivos Latinoamericanos de Nutrición, 60(1), 99-104. http://www.alanrevista.org/ediciones/2010/1/art-15/ 

Lavrado, J., Cabal, G. G., Prudêncio, M., Mota, M. M., Gut, J., Rosenthal, P. J., Díaz, C., Guedes, R. C., Dos Santos, D. J. V. A., Bichenkova, E., Douglas, K. T., Moreira, R., & Paulo, A. (2011). Incorporation of basic side chains into cryptolepine scaffold: Structure−antimalarial activity relationships and mechanistic studies. Journal of Medicinal Chemistry, 54(3), 734-750. https://doi.org/10.1021/jm101383f 

León, G., Herrera, M., Vargas, M., Arguedas, M., Sánchez, A., Segura, Á., Gómez, A., Solano, G., Corrales-Aguilar, E., Risner, K., Narayanan, A., Bailey, C., Villalta, M., Hernández, A., Sánchez, A., Cordero, D., Solano, D., Durán, G., Segura, E., … Alape, A. (2021). Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19. Scientific Reports, 11(1), Artículo 9825. https://doi.org/10.1038/s41598-021-89242-z 

Lomonte, B., Díaz, C., Chaves, F., Fernández, J., Ruiz, M., Salas, M., Zavaleta, A., Calvete, J. J., & Sasa, M. (2020). Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression. Toxicon: X, 7, Artículo 100044. https://doi.org/10.1016/j.toxcx.2020.100044 

Lomonte, B., Díaz Oreiro, C., Gutiérrez, J. M., & Moreno Robles, E. (2020). Métodos de Investigación: Destrezas básicas para el trabajo científico en las disciplinas biomédicas. SEP, Universidad de Costa Rica. https://hdl.handle.net/10669/81733 

Lomonte, B., Gutiérrez, J. M., Ramírez, M., & Díaz, C. (1992). Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies. Toxicon, 30(3), 239-245. https://doi.org/10.1016/0041-0101(92)90866-4 

Montoya-Arroyo, A., Díaz, C., Vaillant, F., & Tamayo-Castillo, G. (2020). Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR. NFS Journal, 20, 48-57. https://doi.org/10.1016/j.nfs.2020.07.003 

Mora, R., Valverde, B., Díaz, C., Lomonte, B., & Gutiérrez, J. M. (2005). A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line. Toxicon, 45(5), 651-660. https://doi.org/10.1016/j.toxicon.2005.01.008 lys 49

Mora-Obando, D., Díaz, C., Angulo, Y., Gutiérrez, J. M., & Lomonte, B. (2014). Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: ¿Are there additional effector mechanisms involved? PeerJ, 2, Artículo e569. https://doi.org/10.7717/peerj.569 

Moreira-Soto, A., Arguedas, M., Brenes, H., Buján, W., Corrales-Aguilar, E., Díaz, C., Echeverri, A., Flores-Díaz, M., Gómez, A., Hernández, A., Herrera, M., León, G., Macaya, R., Kühne, A., Molina-Mora, J. A., Mora, J., Sanabria, A., Sánchez, A., Sánchez, L., … Drexler, J. F. (2021). High efficacy of therapeutic equine hyperimmune antibodies against Sars-Cov-2 variants of concern. Frontiers in Medicine, 8, Artículo 735853. https://doi.org/10.3389/fmed.2021.735853 

Ortiz, N., Delgado-Carazo, J. C., & Díaz, C. (2021). Importance of mevalonate pathway lipids on the growth and survival of primary and metastatic gastric carcinoma cells. Clinical and Experimental Gastroenterology, 14, 217-228. https://doi.org/10.2147/CEG.S310235 

Ortiz, N., Jiménez, M. F., Chaverri, C., Cicció, J. F., & Díaz, C. (2022). Effect on cell growth, viability and migration of geraniol and geraniol-containing essential oil from Lippia alba (Verbenaceae) on gastric carcinoma cells. Journal of Essential Oil Research, 34(1), 65-76. https://doi.org/10.1080/10412905.2021.1975576 

Ortiz, N., & Díaz, C. (2024). Preclinical evaluation of fenretinide against primary and metastatic intestinal type gastric cancer. Oncology Letters, 28(6), Artículo 561. https://doi.org/10.3892/ol.2024.14694 

Ortiz, N., & Díaz, C. (2020). Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer. Oncology Letters, 20(6), 1-1. https://doi.org/10.3892/ol.2020.12183 

Rojas-Azofeifa, D., Sasa, M., Lomonte, B., Diego-García, E., Ortiz, N., Bonilla, F., Murillo, R., Tytgat, J., & Díaz, C. (2019). Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 217, 54-67. https://doi.org/10.1016/j.cbpc.2018.11.021 

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